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Microbiology 
5th Edition 
Lansing M. Prescott 

Prescott, Harley and Klein's 5th edition provides a balanced, comprehensive introduction to all 
major areas of microbiology. Because of this balance, Microbiology, 5/e is appropriate for students 
preparing for careers in medicine, dentistry, nursing, and allied health, as well as research, teaching, 
and industry. Biology and chemistry are prerequisites. The Fifth Edition has been updated 
extensively to reflect the latest discoveries in the field. 
New to This Edition 
_ Every chapter in the book has been updated to reflect the latest discoveries in microbiology, including 
information on genomics, biofilms, mechanisms of toxins, classification, and emerging diseases. The most 
extensive revision has occurred in the areas of genetics, microbial ecology, and immunology where material 
has been updated and reorganized to allow for easier use. 
_ New Genomics chapter: Chapter 15. The genetics coverage has been reorganized for clarity and ease of 
teaching. The genetics section now ends with a completely new chapter on genomics. New Chapter 28 on 
microorganism interactions and microbial ecology! 
_ Newly developed art program--much of the art is new or revised! It incorporates color and style consistency 
throughout so students will easily identify certain topics. 
_ New critical thinking questions have been added to provide practice in analyzing data, predicting outcomes, 
and to teach students how to think logically. 
_ The general organization of the text has been modified to provide a more logical flow of topics and give 
greater emphasis to microbial ecology 
Features 
_ Prescott's textbook contains briefer chapters than most books, but more of them (42). Students will find the 
concise chapters more palatable and less intimidating. Short chapters give the instructor the opportunity to fit 
the text more closely to the instructor's syllabus. Topic flexibility is allowed. 
_There is an outstanding pedagogical system including outlines, concepts, key terms, cross-referencing, 
readings, new critical thinking questions, etc., to help students understand difficult material. 

Microbiology is an exceptionally broad discipline encompassing 
specialties as diverse as biochemistry, cell biology, 
genetics, taxonomy, pathogenic bacteriology, food 
and industrial microbiology, and ecology. A microbiologist must 
be acquainted with many biological disciplines and with all major 
groups of microorganisms: viruses, bacteria, fungi, algae, and protozoa. 
The key is balance. Students new to the subject need an introduction 
to the whole before concentrating on those parts of 
greatest interest to them. This text provides a balanced introduction 
to all major areas of microbiology for a variety of students. Because 
of this balance, the book is suitable for courses with orientations 
ranging from basic microbiology to medical and applied microbiology. 
Students preparing for careers in medicine, dentistry, nursing, 
and allied health professions will find the text just as useful as 
those aiming for careers in research, teaching, and industry. Two 
quarters/semesters each of biology and chemistry are assumed, and 
an overview of relevant chemistry is also provided in appendix I. 
Organization and Approach 
The book is organized flexibly so that chapters and topics may be 
arranged in almost any order. Each chapter has been made as selfcontained 
as possible to promote this flexibility. Some topics are 
essential to microbiology and have been given more extensive 
treatment. 
The book is divided into 11 parts. The first 6 parts introduce the 
foundations of microbiology: the development of microbiology, the 
structure of microorganisms, microbial growth and its control, metabolism, 
molecular biology and genetics, DNA technology and genomics, 
and the nature of viruses. Part Seven is a survey of the microbial 
world. In the fifth edition, the bacterial survey closely 
follows the general organization of the forthcoming second edition 
of Bergey’s Manual of Systematic Bacteriology. Although principal 
attention is devoted to bacteria, eucaryotic microorganisms receive 
more than usual coverage. Fungi, algae, and protozoa are important 
in their own right. The introduction to their biology in chapters 
25–27 is essential to understanding topics as diverse as clinical microbiology 
and microbial ecology. Part Eight focuses on the relationships 
of microorganisms to other organisms and the environment 
(microbial ecology). It also introduces aquatic and terrestrial 
microbiology. Chapter 28 presents the general principles underlying 
microbial ecology and environmental microbiology so that the subsequent 
chapters on aquatic and terrestrial habitats can be used without 
excessive redundancy. The chapter also describes various types 
of microbial interactions such as mutualism, protocooperation, commensalism, 
and predation that occur in the environment. Parts Nine 
and Ten are concerned with pathogenicity, resistance, and disease. 
The three chapters in Part Nine describe normal microbiota, nonspecific 
host resistance, the major aspects of the immune response, 
and medical immunology. Part Ten first covers such essential topics 
as microbial pathogenicity, antimicrobial chemotherapy, and epidemiology. 
Then chapters 38–40 survey the major human microbial 
diseases. The disease survey is primarily organized taxonomically 
on the chapter level; within each chapter diseases are covered according 
to their mode of transmission. This approach provides flexibility 
and allows the student easy access to information concerning 
any disease of interest. The survey is not a simple catalog of diseases; 
diseases are included because of their medical importance and their 
ability to illuminate the basic principles of disease and resistance. 
Part Eleven concludes the text with an introduction to food and industrial 
microbiology. Five appendices aid the student with a review 
of some basic chemical concepts and with extra information about 
important topics not completely covered in the text. 
This text is designed to be an effective teaching tool. A text 
is only as easy for a student to use as it is easy to read. Readability 
has been enhanced by using a relatively simple, direct writing 
style, many section headings, and an organized outline format 
within each chapter. The level of difficulty has been carefully set 
with the target audience in mind. During preparation of the fifth 
edition, every sentence was carefully checked for clarity and revised 
when necessary. The American Society for Microbiology’s 
ASM Style Manual conventions for nomenclature and abbreviations 
have been followed as consistently as possible. 
The many new terms encountered in studying microbiology 
are a major stumbling block for students. This text lessens the 
problem by addressing and reinforcing a student’s vocabulary development 
in three ways: (1) no new term is used without being 
clearly defined (often derivations also are given)—a student does 
not have to be familiar with the terminology of microbiology to 
use this text; (2) the most important terms are printed in boldface 
when first used; and (3) a very extensive, up-to-date, page-referenced 
glossary is included at the end of the text. 
Because illustrations are critical to a student’s learning and 
enjoyment of microbiology, all illustrations are full-color, and 
many excellent color photographs have been used. Color not only 
enhances the text’s attractiveness but also increases each figure’s 
teaching effectiveness. Considerable effort has gone into making 
the art as attractive and useful as possible. Much of the art in the 
xv 
PREFACE 

Prescott, Harley and Klein's 5th edition provides a balanced, comprehensive introduction to all major areas of microbiology. Because of this balance, Microbiology, 5/e is appropriate for students preparing for careers in medicine, dentistry, nursing, and allied health, as well as research, teaching, and industry. Biology and chemistry are prerequisites. The Fifth Edition has been updated extensively to reflect the latest discoveries in the field. 




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